| First Author | Di Cristofano A | Year | 1999 |
| Journal | Science | Volume | 285 |
| Issue | 5436 | Pages | 2122-5 |
| PubMed ID | 10497129 | Mgi Jnum | J:57906 |
| Mgi Id | MGI:1345936 | Doi | 10.1126/science.285.5436.2122 |
| Citation | Di Cristofano A, et al. (1999) Impaired Fas response and autoimmunity in Pten+/- mice. Science 285(5436):2122-5 |
| abstractText | Inactivating mutations in the PTEN tumor suppressor gene, encoding a phosphatase, occur in three related human autosomal dominant disorders characterized by tumor susceptibility. Here it is shown that Pten heterozygous (Pten+/-) mutants develop a lethal polyclonal autoimmune disorder with features reminiscent of those observed in Fas-deficient mutants. Fas-mediated apoptosis was impaired in Pten+/- mice, and T lymphocytes from these mice show reduced activation-induced cell death and increased proliferation upon activation. Phosphatidylinositol (PI) 3-kinase inhibitors restored Fas responsiveness in Pten+/- cells. These results indicate that Pten is an essential mediator of the Fas response and a repressor of autoimmunity and thus implicate the PI 3-kinase/Akt pathway in Fas-mediated apoptosis. |
