| Primary Identifier | IPR021066 | Type | Family |
| Short Name | FPI1 |
| description | This entry represents fungal proteinase inhibitors found mainly in arthropodes, including fungal protease inhibitor-1 (FPI-1) from Antheraea mylitta (Tasar silkworm). FPI1 inhibits trypsin and chymotrypsin proteases from the fungi Aspergillus oryzae and Rhizopus oryzae. However, they do not inhibit papain-like proteases from the bacterium Bacillus licheniformis []. The crystal structure of this protein was solved using the single isomorphous replacement with anomalous scattering (SIRAS), which revealed that it is a single domain protein possessing a unique fold that consists of three helices and five β-strands stabilized by a network of six disulfide bonds []. Members of this family belong to MEROPS inhibitor family I83, clan JH. |
