| First Author | Wang Z | Year | 1995 |
| Journal | J Immunol | Volume | 155 |
| Issue | 8 | Pages | 3722-5 |
| PubMed ID | 7561075 | Mgi Jnum | J:29252 |
| Mgi Id | MGI:76783 | Doi | 10.4049/jimmunol.155.8.3722 |
| Citation | Wang Z, et al. (1995) Induction of bcl-x by CD40 engagement rescues sIg-induced apoptosis in murine B cells. J Immunol 155(8):3722-5 |
| abstractText | CD40L, a membrane protein of activated T cells, interacts with the B cell receptor CD40. This interaction has been implicated in the rescue of germinal center B cells from apoptosis and in the rescue of WEHI-231 B lymphoma cells from sIg-induced apoptosis. In this report, we have demonstrated that the signal mediated by CD40L acts upon bcl-x, a bcl-2 homologue. bcl-x expression is strongly enhanced by CD40 receptor engagement, while there is little or no induction by sIg cross-linking. The expression of bax and bcl-2 is not significantly affected by either CD40L or sIg cross-linking. Antisense but not sense phosphorothioate oligonucleotide for bcl-x can partially block this CD40-mediated apoptotic rescue. This result suggests that the up-regulation of bcl-x by CD40L plays an important role in CD40-mediated apoptotic rescue in murine B cells. |
