| Primary Identifier | MGI:1336166 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 12633 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables peptidase activator activity. Involved in several processes, including negative regulation of myoblast fusion; skeletal muscle atrophy; and skeletal myofibril assembly. Acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway; negative regulation of necroptotic process; and response to bacterium. Located in cytoplasm. Is expressed in several structures, including central nervous system; gut; heart; peripheral nervous system ganglion; and retina. Orthologous to human CFLAR (CASP8 and FADD like apoptosis regulator). PHENOTYPE: Homozygous mutation of this gene results in embryonic lethality by E10.5. Mutant embryos exhibit cardiac developmental abnormalities and pooling of blood in the head and abdominal regions. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
