| First Author | Shen R | Year | 2002 |
| Journal | Mol Cell Biol | Volume | 22 |
| Issue | 10 | Pages | 3230-6 |
| PubMed ID | 11971956 | Mgi Jnum | J:76243 |
| Mgi Id | MGI:2178901 | Doi | 10.1128/MCB.22.10.3230-3236.2002 |
| Citation | Shen R, et al. (2002) Grap negatively regulates T-cell receptor-elicited lymphocyte proliferation and interleukin-2 induction. Mol Cell Biol 22(10):3230-6 |
| abstractText | Grb-2-related adaptor protein (Grap) is a Grb2-like SH3-SH2-SH3 adaptor protein with expression restricted to lymphoid tissues. Grap(-/-) lymphocytes isolated from targeted Grap-deficient mice exhibited enhanced proliferation, interleukin-2 production, and c-fos induction in response to mitogenic T-cell receptor (TCR) stimulation, compared to wild-type cells. Ectopic expression of Grap led to a suppression of Elk-1-directed transcription induced by the Ras/Erk pathway, without having effects on gene expression mediated by Jnk and p38 mitogen-activated protein kinases. Together, these data suggest that Grap, unlike Grb2, acts as a negative regulator of TCR-stimulated intracellular signaling by downregulating signal relay through the Ras/Erk pathway. |
