| First Author | Ohba N | Year | 2004 |
| Journal | Neurosci Lett | Volume | 359 |
| Issue | 3 | Pages | 159-62 |
| PubMed ID | 15050688 | Mgi Jnum | J:131484 |
| Mgi Id | MGI:3773800 | Doi | 10.1016/j.neulet.2004.02.029 |
| Citation | Ohba N, et al. (2004) Transgenic mouse overexpressing the Akt reduced the volume of infarct area after middle cerebral artery occlusion. Neurosci Lett 359(3):159-62 |
| abstractText | Transgenic mouse lines expressing the active form Akt gene under the control of the damage-induced neuronal endopeptidase (DINE) promoter were made from three different founder mice, and its neuroprotective potential against ischemic brain damage was investigated. Twenty-four hours after middle cerebral artery occlusion, two DINE-Akt-transgenic mouse lines displayed reductions of the infarcted area by 35% compared to the wild-type littermate. RT-PCR assays showed a high level of transgene in response to ischemic brain damage in these lines. These results suggest that the DINE promoter is a useful promoter, which responds to neuronal insults and that the Akt-induced neuroprotective effect against ischemic damage is potent in vivo. |
