| Primary Identifier | MGI:97806 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 19255 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables STAT family protein binding activity and protein tyrosine phosphatase activity. Involved in several processes, including hemopoiesis; negative regulation of leukocyte differentiation; and regulation of signal transduction. Acts upstream of or within insulin receptor signaling pathway and negative regulation of transcription by RNA polymerase II. Located in nucleus. Is active in endosome lumen. Is expressed in several structures, including genitourinary system; heart; hemolymphoid system gland; lower jaw; and midbrain. Orthologous to human PTPN2 (protein tyrosine phosphatase non-receptor type 2). PHENOTYPE: Mice homozygous for disruptions in this gene have a reduced life span, abnormalities of the hematopoietic system and an increased succeptibility to inflammatory disease. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
