| First Author | Artigiani S | Year | 2004 |
| Journal | EMBO Rep | Volume | 5 |
| Issue | 7 | Pages | 710-4 |
| PubMed ID | 15218527 | Mgi Jnum | J:203408 |
| Mgi Id | MGI:5526939 | Doi | 10.1038/sj.embor.7400189 |
| Citation | Artigiani S, et al. (2004) Plexin-B3 is a functional receptor for semaphorin 5A. EMBO Rep 5(7):710-4 |
| abstractText | Semaphorins are a large family of molecular cues implicated in neural development and in a variety of functions outside the nervous system. Semaphorin 5A (Sema5A) is a transmembrane semaphorin, containing seven thrombospondin type-1 repeats, which was recently found to control axon guidance. Here we show that plexin-B3 is a high-affinity receptor specific for Sema5A. We further demonstrate that plexin-B3 activation by Sema5A mediates functional responses in plexin-B3-expressing cells (either fibroblasts, epithelial and primary endothelial cells). In addition, Sema5A can trigger the intracellular signalling of the hepatocyte growth factor/scatter factor receptor, Met, associated in a complex with plexin-B3. We thus conclude that Sema5A is able to elicit multiple functional responses through its receptor plexin-B3. |
