Primary Identifier | MGI:2445439 | Allele Type | Targeted |
Gene | Rb1 | Transmission | Germline |
Strain of Origin | 129S6/SvEvTac | Is Recombinase | false |
Is Wild Type | false |
molecularNote | This mutant is derived from Rb1tm1Jyjw. The floxed neo cassette in intron 25 was removed by mating Rb1tm1Jyjw animals to cre-expressing line TgN(Prm-cre)58Og. Resulting progeny contain the aspartic acid to alanine mutation in the caspase cleavage site of exon 25 and the diagnostic EcoRI site in intron 24. |