| Primary Identifier | MGI:1916882 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 69632 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable G protein-coupled receptor binding activity and guanyl-nucleotide exchange factor activity. Involved in regulation of blood pressure. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and skin. Orthologous to human ARHGEF12 (Rho guanine nucleotide exchange factor 12). PHENOTYPE: Mice homozygous for a null allele exhibit decreased sensitivity to certain vasoconstrictors and resistance to salt-induced hypertension. Mice homozygous for a different knock-out allele exhibit partial prenatal lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
