| First Author | Kometani K | Year | 2004 |
| Journal | Trends Mol Med | Volume | 10 |
| Issue | 8 | Pages | 401-8 |
| PubMed ID | 15310461 | Mgi Jnum | J:92899 |
| Mgi Id | MGI:3054707 | Doi | 10.1016/j.molmed.2004.06.004 |
| Citation | Kometani K, et al. (2004) Rap1 and SPA-1 in hematologic malignancy. Trends Mol Med 10(8):401-8 |
| abstractText | Rap1 is a member of the Ras family of GTPases and, depending on the cellular context, has an important role in the regulation of proliferation or cell adhesion. In lymphohematopoietic tissues, SPA-1 is a principal Rap1 GTPase-activating protein. Mice that are deficient for the SPA-1 gene develop age-dependent progression of T-cell immunodeficiency followed by a spectrum of late onset myeloproliferative disorders, mimicking human chronic myeloid leukemia. Recent studies reveal that deregulated Rap1 activation in SPA-1-deficient mice causes enhanced expansion of the bone marrow hematopoietic progenitors, but induces progressive unresponsiveness or anergy in T cells. Rap1 and its regulator, SPA-1, could, therefore, provide unique molecular targets for the control of human hematologic malignancy. |
