| Primary Identifier | IPR030770 | Type | Family |
| Short Name | SIPA1L1 |
| description | SIPA1-like proteins share sequence similarity with signal-induced proliferation-associated protein 1 (SIPA1), which is a GTPase activator for the nuclear Ras-related regulatory proteins Rap1 and Rap2 [, ]. This entry represents SIPA1L1 (also known as SPAR), which has been identified as a Rap-specific GTPase-activating protein. SPAR is a postsynaptic regulator of synaptic morphology and function []. It interacts with the scaffold protein PSD-95 and forms a complex with PSD-95 and NMDA receptors in brain. It regulates F-Actin organisation and recruits PSD-95 to F-actin []. |
