| Primary Identifier | MGI:109536 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 16427 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in hyaluronan metabolic process. Predicted to act upstream of or within acute-phase response. Located in cytoplasm and plasma membrane. Is expressed in several structures, including heart; intestine; liver; lung; and male reproductive gland or organ. Human ortholog(s) of this gene implicated in intermediate coronary syndrome and myocardial infarction. Orthologous to human ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4). PHENOTYPE: Mice homozygous for a knock-out allele are viable, fertile and overtly normal. Surprisingly, IL-6/STAT3 signaling is significantly suppressed in mutant liver tissues but hepatocytes remain well differentiated. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
