| First Author | Hong L | Year | 1998 |
| Journal | Neuroreport | Volume | 9 |
| Issue | 6 | Pages | 1239-43 |
| PubMed ID | 9601701 | Mgi Jnum | J:49927 |
| Mgi Id | MGI:1289592 | Doi | 10.1097/00001756-199804200-00051 |
| Citation | Hong L, et al. (1998) The cDNA cloning and ontogeny of mouse alpha-synuclein. Neuroreport 9(6):1239-43 |
| abstractText | Alpha-synuclein has been implicated in the pathogenesis of Parkinson's disease. To investigate the role of alpha-synuclein in the brain, the cDNA clone encoding the mouse cognate of the human alpha-synuclein was isolated from a mouse brain cDNA library. The open reading frame coded for 140 amino acids that share 95% identity with human alpha-synuclein. Northern blot analysis showed that alpha-synuclein mRNA was primarily expressed in brain and spleen of adult mouse. In situ hybridization histochemistry revealed the highest expression of alpha-synuclein mRNA in the hippocampal formation and neocortex of the adult mouse. alpha- Synuclein mRNA expression in the brain was first observed in the hippocampus and neocortex on postnatal day 1. Levels of alpha-synuclein mRNA in these forebrain areas were nearly maximal at postnatal day 7 and remained relatively high until the adult stage. alpha-Synuclein mRNA was expressed in the liver transiently during embryogenesis. |
