| Primary Identifier | IPR039520 | Type | Domain |
| Short Name | CBL-B_RING-HC |
| description | Cbl-b, also known as RNF56, has been identified as a regulator of antigen-specific, T cell-intrinsic, peripheral immune tolerance, a state also known as clonal anergy. It may inhibit activation of the p85 subunit of phosphoinositide 3-kinase (PI3K), protein kinase C-theta (PKC-theta) []and negatively regulates T-cell receptor-induced transcription factor nuclear factor kappaB (NF-kappaB) activation []. In addition, Cbl-b may target multiple signaling molecules involved in transforming growth factor (TGF)-beta-mediated transactivation pathways []. Cbl-b contains a tyrosine-kinase-binding domain (TKB, also known as the phosphotyrosine binding PTB domain, is composed of a four helix-bundle, a Ca2+ binding EF-hand and a highly variant SH2 domain), a proline rich domain, a nuclear localization signal, a C3HC4-type RING-HC finger and an ubiquitin-associated (UBA) domain []. This entry represents the C3HC4-type RING-HC finger. |
