| Primary Identifier | MGI:1353651 | Organism | mouse, laboratory |
| Chromosome | 14 | NCBI Gene Number | 30877 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables GTP binding activity. Predicted to be involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of protein localization to chromosome, telomeric region; and stem cell division. Located in nucleolus and nucleoplasm. Is expressed in several structures, including brain ventricular layer; gut; jaw; liver lobe; and lung. Orthologous to human GNL3 (G protein nucleolar 3). PHENOTYPE: Homozygous disruption of this gene leads to early embryonic loss as blastocysts fail to enter the S phase. MEFs heterozygous for a gene trap allele have reduced proliferative capacity while MEFs heterozygous for a null allele show reduced doubling rates,increased apoptosis and premature senescence. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
