| First Author | Guimarães FR | Year | 2018 |
| Journal | Clin Immunol | Volume | 190 |
| Pages | 74-83 | PubMed ID | 28965882 |
| Mgi Jnum | J:284986 | Mgi Id | MGI:6392964 |
| Doi | 10.1016/j.clim.2017.08.022 | Citation | Guimaraes FR, et al. (2018) The inhibition of 5-Lipoxygenase (5-LO) products leukotriene B4 (LTB4) and cysteinyl leukotrienes (cysLTs) modulates the inflammatory response and improves cutaneous wound healing. Clin Immunol 190:74-83 |
| abstractText | To analyze the participation of the enzyme 5-lipoxygenase (5-LO) in skin repair, WT wounds were compared to those in 5-LO deficient mice (5-LO(-/-)), which presented faster closure and reduced inflammatory infiltrate in the skin, together with increased CD4 regulatory T cells markers in the draining lymph nodes. The 5-LO(-/-) wounds also had diminished TNF-alpha, CCL11, CCL7, CCL2, CXCL9, CCR1 and CXCR2 mRNA expression in the lesions, besides differential extracellular matrix remodeling. Furthermore, when cysteinyl leukotriene (cysLT) and leukotriene (LTB4) receptors were antagonized in WT mice, there was a remarkable reduction in TNF-alpha expression and faster skin healing, similarly to the findings in 5-LO(-/-) animals. Finally, our results suggested that 5-LO products, in special cysLT and LTB4, underline skin inflammation that follows skin injury and their neutralization may be an important strategy to improve cutaneous healing. |
