| Primary Identifier | IPR005542 | Type | Domain |
| Short Name | PBX_PBC_dom |
| description | Pbx proteins are members of the TALE (three-amino-acid loop extension) family of atypical homeodomain proteins, whose membersare characterised by a three-residue insertion between helix 1 and 2 and plays essential roles during embryonic development by participating in interactive TF networks. The heterodimerization of TALE proteins serves as a trigger for precise execution of developmental programs. Examinationof Pbx1 has shown that, in addition to the homeodomain, a short 16-residue C-terminal tail is essential for maximal cooperative interactions withHox partners as well as for maximal monomeric binding of Pbx1 to DNA. The PCB domain is a bipartite acidic domain that can be further subdivided into an A and B region [, , ]. |
