| First Author | Frigerio S | Year | 2002 |
| Journal | Nat Med | Volume | 8 |
| Issue | 12 | Pages | 1414-20 |
| PubMed ID | 12415259 | Mgi Jnum | J:132575 |
| Mgi Id | MGI:3776321 | Doi | 10.1038/nm792 |
| Citation | Frigerio S, et al. (2002) Beta cells are responsible for CXCR3-mediated T-cell infiltration in insulitis. Nat Med 8(12):1414-20 |
| abstractText | T cell-mediated loss of insulin-secreting beta cells in the islets of Langerhans is the hallmark of type 1 diabetes. The molecular basis for the directed migration of autoreactive T cells leading to insulitis is presently unknown. Here we demonstrate that in response to inflammation, beta cells secrete the chemokines CXC ligand 10 and CXC ligand 9, which specifically attract T-effector cells via the CXC chemokine receptor 3. In mice deficient for this receptor, the onset of type 1 diabetes is substantially delayed. Thus, in the absence of known etiological agents, CXC receptor 3 represents a novel target for therapeutic interference early in type 1 diabetes. |
