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Protein Coding Gene : Mapkap1 mitogen-activated protein kinase associated protein 1
Primary Identifier  MGI:2444554 Organism  mouse, laboratory
Chromosome  2 NCBI Gene Number  227743
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable several functions, including enzyme binding activity; phosphatidylinositol-3,4-bisphosphate binding activity; and phospholipid binding activity. Involved in positive regulation of peptidyl-serine phosphorylation and regulation of cellular response to oxidative stress. Part of TORC2 complex. Is expressed in genitourinary system; gut gland; heart; nervous system; and trachea. Orthologous to human MAPKAP1 (MAPK associated protein 1).
PHENOTYPE: Homozygous null mice exhibit embryonic lethality due to early developmental abnormalities. Mutant mouse embryonic fibroblasts display increased susceptibility to stress-induced apoptosis. [provided by MGI curators]
  • synonyms:
  • RIKEN cDNA D230039K05 gene,
  • D230039K05Rik,
  • expressed sequence AI591529,
  • AI591529,
  • MGI:2139008,
  • Sin1,
  • mitogen-activated protein kinase associated protein 1,
  • Mapkap1
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19 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

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Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

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