| First Author | Zheng Y | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 16 | Pages | 2396-403 |
| PubMed ID | 22684007 | Mgi Jnum | J:187000 |
| Mgi Id | MGI:5435108 | Doi | 10.1016/j.febslet.2012.05.054 |
| Citation | Zheng Y, et al. (2012) miR-376a suppresses proliferation and induces apoptosis in hepatocellular carcinoma. FEBS Lett 586(16):2396-403 |
| abstractText | MicroRNAs are known to be involved in the pathogenesis of hepatocellular carcinoma (HCC). This study aims to explore the potential biological function of miR-376a, which was found to be inhibited after partial hepatectomy, in HCC. We discovered that miR-376a was frequently down-regulated in HCC cell lines and HCC tissues, while higher relative level of miR-376a was significantly associated with high serum AFP level. Over-expression of miR-376a not only inhibited proliferation but induced apoptosis in Huh7 cells. Additionally, p85alpha (PIK3R1) was identified as a direct and functional target of miR-376a in Huh7 cells. Moreover, we confirmed that p85alpha and miR-376a were inversely correlated in HCC. These findings suggest that down-regulation of miR-376a may contribute to the development of HCC by targeting p85alpha. |
