| Primary Identifier | MGI:1933302 | Organism | mouse, laboratory |
| Chromosome | 19 | NCBI Gene Number | 93679 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable several functions, including mitogen-activated protein kinase kinase kinase binding activity; protein homodimerization activity; and transcription coactivator activity. Involved in defense response to symbiont; negative regulation of viral entry into host cell; and negative regulation of viral transcription. Acts upstream of or within positive regulation of protein localization to nucleus and stem cell population maintenance. Located in cytosol and nucleus. Is expressed in several structures, including central nervous system; female reproductive system; and urinary system. Orthologous to human TRIM8 (tripartite motif containing 8). PHENOTYPE: Homozygous inactivation of this gene relieves hepatic ischemia/reperfusion injury and improves pressure overload-induced cardiac hypertrophy. Mice homozygous for a null allele show increased susceptibility to poly(I:C)-, LPS- and Salmonella typhimurium infection-induced death. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
