| First Author | Vincent SR | Year | 2000 |
| Journal | Biochem Biophys Res Commun | Volume | 279 |
| Issue | 2 | Pages | 482-6 |
| PubMed ID | 11118312 | Mgi Jnum | J:66497 |
| Mgi Id | MGI:1928558 | Doi | 10.1006/bbrc.2000.3984 |
| Citation | Vincent SR, et al. (2000) A novel RING finger-B box-coiled-coil protein, GERP. Biochem Biophys Res Commun 279(2):482-6 |
| abstractText | The RING finger domain occurs in a wide variety of proteins involved in cellular regulation. The polymerase chain reaction was used to search for novel RING finger proteins, using primers derived from expressed sequence tags (ests). A cDNA encoding a novel RING finger protein expressed in brain, lung, breast, placenta, kidney, muscle, and germinal center B cells is described. The human gene is expressed in a variety of tumors, including anaplastic oligodendroglioma and maps to chromosome 10q24.3, a region showing frequent deletion or loss of heterozygosity in glioblastomas. It was therefore designated glioblastoma expressed RING finger protein (GERP). GERP contains an N-terminal RING finger, followed by two B-boxes and a coiled-coil, and thus belongs to the RBCC subfamily of RING finger proteins. The structure of this protein and its mapping to a locus thought to harbor tumor suppressor genes indicates that it may be a new tumor suppressor gene important in gliomas and other malignancies. Copyright 2000 Academic Press. |
