| First Author | Müller N | Year | 2019 |
| Journal | Eur J Immunol | Volume | 49 |
| Issue | 3 | Pages | 504-507 |
| PubMed ID | 30585320 | Mgi Jnum | J:273468 |
| Mgi Id | MGI:6283310 | Doi | 10.1002/eji.201847818 |
| Citation | Muller N, et al. (2019) XIAP deficiency in hematopoietic recipient cells drives donor T-cell activation and GvHD in mice. Eur J Immunol 49(3):504-507 |
| abstractText | Patients with X-linked lymphoproliferative syndrome type 2 (XLP-2) (BIRC4 deficiency) suffer from hyperinflammation often observed during the conditioning regimen prior to allogeneic bone marrow transplant. This article shows that in mice hematopoietic recipient cells contribute to graft-versus-host disease by the secretion of elevated levels of proinflammatory cytokines during engraftment when BIRC4 is absent. |
