| First Author | Hashimoto N | Year | 1996 |
| Journal | Horm Res | Volume | 46 Suppl 1 |
| Pages | 11-4 | PubMed ID | 8864742 |
| Mgi Jnum | J:35079 | Mgi Id | MGI:82533 |
| Doi | 10.1159/000185171 | Citation | Hashimoto N (1996) Role of c-mos proto-oncogene product in the regulation of mouse oocyte maturation. Horm Res 46 Suppl 1:11-4 |
| abstractText | The c-mos proto-oncogene product (Mos) is essential for the initiation of oocyte maturation, for the suppression of DNA synthesis during meiosis, and for the second metaphase arrest in Xenopus. To clarify the function of Mos in mice, c-mos-deficient mice were generated by gene targeting. We cultured oocytes from c-mos-deficient females to determine the role of Mos in oocyte maturation. c-mos-deficient oocytes matured normally to the second metaphase, but were activated without fertilization. Thus, prevention of parthenogenetic activation might be an ultimate biological function of Mos in animal oocytes. |
