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Allele : Erbb4<tm1.1Line> erb-b2 receptor tyrosine kinase 4; targeted mutation 1.1, Lin Mei

Primary Identifier  MGI:6154872 Allele Type  Targeted
Gene  Erbb4 Transmission  Germline
Strain of Origin  129S6/SvEvTac and C57BL/6J Is Recombinase  false
Is Wild Type  false
molecularNote  A floxed neo cassette and T796G mutation in exon 20 were inserted via homologous recombination. Cre-mediated recombination removed the neo cassette. This mutation enlarges the ATP binding pocket and allows specific inhibition by 4-amino-1-tert-butyl-3-(1'-naphthylmethyl)pyrazolo[3,4-d]pyrimidine.
  • mutations:
  • Insertion
  • synonyms:
  • T796G,
  • T796G
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

4 Publication categories

Trail: Allele