Primary Identifier | MGI:6154872 | Allele Type | Targeted |
Gene | Erbb4 | Transmission | Germline |
Strain of Origin | 129S6/SvEvTac and C57BL/6J | Is Recombinase | false |
Is Wild Type | false |
molecularNote | A floxed neo cassette and T796G mutation in exon 20 were inserted via homologous recombination. Cre-mediated recombination removed the neo cassette. This mutation enlarges the ATP binding pocket and allows specific inhibition by 4-amino-1-tert-butyl-3-(1'-naphthylmethyl)pyrazolo[3,4-d]pyrimidine. |