| First Author | Kagimoto Y | Year | 2008 |
| Journal | J Leukoc Biol | Volume | 83 |
| Issue | 1 | Pages | 165-72 |
| PubMed ID | 17906118 | Mgi Jnum | J:130037 |
| Mgi Id | MGI:3770599 | Doi | 10.1189/jlb.0307137 |
| Citation | Kagimoto Y, et al. (2008) A regulatory role of interleukin 15 in wound healing and mucosal infection in mice. J Leukoc Biol 83(1):165-72 |
| abstractText | IL-15 plays a critical role in the development and maturation of gammadelta intraepithelial T lymphocytes (IEL), which are known to play important roles in wound healing and resolving inflammation in mice. In this study, we found that IL-15 transgenic (Tg) mice, under the control of a MHC Class I promoter, exhibited accelerated wound healing but were highly susceptible to genital infection with HSV-2. The IEL in the skin and reproductive organs of IL-15 Tg mice produced an aberrantly higher level of TGF-beta1 upon TCR triggering than in control mice. In vivo neutralization of TGF-beta ameliorated the susceptibility of IL-15 Tg mice to genital HSV-2 infection. Taken together, overexpression of IL-15 may stimulate IEL to produce TGF-beta1, promoting wound healing but impeding protection against genital HSV-2 infection. |
