Primary Identifier | MGI:1916160 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 68910 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including central nervous system; male reproductive system; and urinary system. Orthologous to human ZNF467 (zinc finger protein 467). PHENOTYPE: Mice homozygous for a null allele are small with less body fat, exhibit higher trabecular bone and cortical bone area, reduced marrow adipocyte numbers, improved glucose tolerance, and are resistant to ovariectomy-induced adiposity and high-fat diet-induced adiposity and weight gain. [provided by MGI curators] |