| First Author | Kadoya T | Year | 2005 |
| Journal | Mol Cell Biol | Volume | 25 |
| Issue | 19 | Pages | 8619-30 |
| PubMed ID | 16166642 | Mgi Jnum | J:101360 |
| Mgi Id | MGI:3603882 | Doi | 10.1128/MCB.25.19.8619-8630.2005 |
| Citation | Kadoya T, et al. (2005) JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity. Mol Cell Biol 25(19):8619-30 |
| abstractText | We report the identification and characterization of JAMP (JNK1 [Jun N-terminal kinase 1]-associated membrane protein), a predicted seven-transmembrane protein that is localized primarily within the plasma membrane and associates with JNK1 through its C-terminal domain. JAMP association with JNK1 outcompetes JNK1 association with mitogen-activated protein kinase phosphatase 5, resulting in increased and prolonged JNK1 activity following stress. Elevated expression of JAMP following UV or tunicamycin treatment results in sustained JNK activity and a higher level of JNK-dependent apoptosis. Inhibition of JAMP expression by RNA interference reduces the degree and duration of JNK activation and concomitantly the level of stress-induced apoptosis. Through its regulation of JNK1 activity, JAMP emerges as a membrane-anchored regulator of the duration of JNK1 activity in response to diverse stress stimuli. |
