| First Author | Tekamp-Olson P | Year | 1990 |
| Journal | J Exp Med | Volume | 172 |
| Issue | 3 | Pages | 911-9 |
| PubMed ID | 2201751 | Mgi Jnum | J:10692 |
| Mgi Id | MGI:59139 | Doi | 10.1084/jem.172.3.911 |
| Citation | Tekamp-Olson P, et al. (1990) Cloning and characterization of cDNAs for murine macrophage inflammatory protein 2 and its human homologues. J Exp Med 172(3):911-9 |
| abstractText | A cDNA clone of murine macrophage inflammatory protein 2 (MIP-2) has been isolated from a library prepared from lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and the nucleotide sequence determined. This cDNA was used to clone cDNAs for human homologues of MIP-2 from a library prepared from phorbol myristate acetate-treated and LPS-stimulated U937 cells. Two homologues were isolated and sequenced. Human MIP-2 alpha and MIP-2 beta are highly homologous to each other and to a previously isolated gene, human gro/melanoma growth-stimulating activity (MGSA). These three human genes, MIP-2 alpha, MIP-2 beta, and gro/MGSA, constitute a sub-family within the cytokine family represented by platelet factor 4 and interleukin 8. |
