| Primary Identifier | MGI:3603594 | Organism | mouse, laboratory |
| Chromosome | 12 | NCBI Gene Number | 399558 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables chemorepellent activity and fibroblast growth factor receptor binding activity. Involved in basement membrane organization; cell adhesion involved in heart morphogenesis; and fibroblast growth factor receptor signaling pathway. Acts upstream of or within axon guidance; positive regulation of synapse assembly; and regulation of neuron migration. Located in cell-cell junction; extracellular space; and plasma membrane. Is active in glutamatergic synapse; postsynaptic membrane; and presynaptic membrane. Colocalizes with focal adhesion. Is expressed in several structures, including branchial arch; central nervous system; embryo mesenchyme; heart; and sensory organ. Orthologous to human FLRT2 (fibronectin leucine rich transmembrane protein 2). PHENOTYPE: Mice homozygous for a knock-out allele exhibit embryonic, fetal, and postnatel lethality with few mice surviving to weaning due to defects in epicardium, myocardium, and endocardium development. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
