| First Author | García-Fernández M | Year | 2010 |
| Journal | Genes Dev | Volume | 24 |
| Issue | 20 | Pages | 2282-93 |
| PubMed ID | 20952537 | Mgi Jnum | J:165092 |
| Mgi Id | MGI:4836271 | Doi | 10.1101/gad.1970110 |
| Citation | Garcia-Fernandez M, et al. (2010) Sept4/ARTS is required for stem cell apoptosis and tumor suppression. Genes Dev 24(20):2282-93 |
| abstractText | Inhibitor of Apoptosis Proteins (IAPs) are frequently overexpressed in tumors and have become promising targets for developing anti-cancer drugs. IAPs can be inhibited by natural antagonists, but a physiological requirement of mammalian IAP antagonists remains to be established. Here we show that deletion of the mouse Sept4 gene, which encodes the IAP antagonist ARTS, promotes tumor development. Sept4-null mice have increased numbers of hematopoietic stem and progenitor cells, elevated XIAP protein, increased resistance to cell death, and accelerated tumor development in an Emu-Myc background. These phenotypes are partially suppressed by inactivation of XIAP. Our results suggest that apoptosis plays an important role as a frontline defense against cancer by restricting the number of normal stem cells. |
