| First Author | Yarden Y | Year | 1986 |
| Journal | Nature | Volume | 323 |
| Issue | 6085 | Pages | 226-32 |
| PubMed ID | 3020426 | Mgi Jnum | J:8434 |
| Mgi Id | MGI:56901 | Doi | 10.1038/323226a0 |
| Citation | Yarden Y, et al. (1986) Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature 323(6085):226-32 |
| abstractText | The primary structure of the receptor for platelet-derived growth factor (PDGF), determined by means of cloning a cDNA that encodes the murine pre-PDGF receptor, is closely related to that of the v-kit oncogene product and the receptor for macrophage colony stimulating factor (CSF-1). Common structural features include the presence of long sequences that interrupt the tyrosine-specific protein kinase domains of each molecule. The PDGF and CSF-1 receptors also share a characteristic distribution of extracellular cysteine residues. Ubiquitin is covalently bound to the purified PDGF receptor, the human gene for which is on chromosome 5. |
