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Protein Coding Gene : Crb3 crumbs family member 3

Primary Identifier  MGI:2670904 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  224912
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable SH3 domain binding activity. Involved in positive regulation of cell junction assembly. Located in apical part of cell. Part of subapical complex. Is expressed in several structures, including central nervous system; early conceptus; and retina. Orthologous to human CRB3 (crumbs cell polarity complex component 3).
PHENOTYPE: Mice homozygous for a knock-out allele exhibit neonatal lethality likely due to respiratory distress, abnormal pulmonary alveolus morphology, kidney cysts and abnormal small intestinal morphology. [provided by MGI curators]
  • synonyms:
  • AU015179,
  • MGI:2146999,
  • expressed sequence AU041752,
  • crumbs family member 3,
  • Crb3,
  • expressed sequence AU015179,
  • AU041752,
  • MGI:2146967

Features --> Cross References

Genome

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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

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Literature

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