| First Author | Calogero RA | Year | 2007 |
| Journal | Breast Cancer Res | Volume | 9 |
| Issue | 4 | Pages | 211 |
| PubMed ID | 17705881 | Mgi Jnum | J:138100 |
| Mgi Id | MGI:3804167 | Doi | 10.1186/bcr1745 |
| Citation | Calogero RA, et al. (2007) Inflammation and breast cancer. Inflammatory component of mammary carcinogenesis in ErbB2 transgenic mice. Breast Cancer Res 9(4):211 |
| abstractText | ABSTRACT : This review addresses genes differentially expressed in the mammary gland transcriptome during the progression of mammary carcinogenesis in BALB/c mice that are transgenic for the rat neu (ERBB2, or HER-2/neu) oncogene (BALB-neuT664V-E mice). The Ingenuity knowledge database was used to characterize four functional association networks whose hub genes are directly linked to inflammation (specifically, the genes encoding IL-1beta, tumour necrosis factor, interferon-gamma, and monocyte chemoattractant protein-1/CC chemokine ligand-2) and are increasingly expressed during such progression. In silico meta-analysis in a human breast cancer dataset suggests that proinflammatory activation in the mammary glands of these mice reflects a general pattern of human breast cancer. |
