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Publication : p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis.

First Author  Teis D Year  2006
Journal  J Cell Biol Volume  175
Issue  6 Pages  861-8
PubMed ID  17178906 Mgi Jnum  J:119075
Mgi Id  MGI:3701147 Doi  10.1083/jcb.200607025
Citation  Teis D, et al. (2006) p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis. J Cell Biol 175(6):861-8
abstractText  The extracellular signal-regulated kinase (ERK) cascade regulates proliferation, differentiation, and survival in multicellular organisms. Scaffold proteins regulate intracellular signaling by providing critical spatial and temporal specificity. The scaffold protein MEK1 (mitogen-activated protein kinase and ERK kinase 1) partner (MP1) is localized to late endosomes by the adaptor protein p14. Using conditional gene disruption of p14 in mice, we now demonstrate that the p14-MP1-MEK1 signaling complex regulates late endosomal traffic and cellular proliferation. This function its essential for early embryogenesis and during tissue homeostasis, as revealed by epidermis-specific deletion of p14. These findings show that endosomal p14-MP1-MEK1 signaling has a specific and essential function in vivo and, therefore, indicate that regulation of late endosomal traffic by extracellular signals is required to maintain tissue homeostasis.
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