| First Author | Moncure CW | Year | 1998 |
| Journal | Int J Exp Pathol | Volume | 79 |
| Issue | 3 | Pages | 183-92 |
| PubMed ID | 9741360 | Mgi Jnum | J:48695 |
| Mgi Id | MGI:1274880 | Doi | 10.1046/j.1365-2613.1998.00064.x |
| Citation | Moncure CW, et al. (1998) Comparative histopathology in mouse typhoid among genetically diverse mice. Int J Exp Pathol 79(3):183-92 |
| abstractText | Genetically resistant CBA and A/J mice and susceptible BALB/c and C57BL/6 mice were challenged with either an identical infective dose or a minimal lethal dose of Salmonella typhimurium. The histopathological progression of the disease was examined in tissue sections prepared by the JB-4 Plus resin embedding method and compared between the resistant and susceptible mice. In a fatal disease, the lesions in both animal hosts began with focal abscesses within the first three days post infection. Mononuclear cell infiltration started by day 4 and transformed the lesions into granulomata. Well-formed granulomata were evident by day 7 and persisted in sublethally infected resistant mice. Massive bacterial proliferation and extensive tissue degeneration marked the terminal stage of a lethal challenge. There were no distinguishable features that would identify the tissue response to infection in a resistant host from a susceptible one, except that the lesions in the sublethally infected resistant mice advanced slower and were discrete and self-limiting. |
