| Primary Identifier | IPR020466 | Type | Family |
| Short Name | IL-15_mml |
| description | Interleukins (IL) are a group of cytokinesthat play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells. Interleukin-15 (IL-15) has a variety of biological functions, including stimulation and maintenance of cellular immune responses []. It is required for division of CD8+ T cells of memory phenotype - a process that is increased by inhibition of IL-2 []. The numbers of CD8+ memory T cells in animals may, therefore, be controlled by a balance between IL-15 and -2. IL-15 has been identified in mammals, birds and fish. This entry represents Mammalian IL-15s, that are expressed in a number of different tissues and cell types. Within the immune system, they are mainly produced by monocytes and macrophages []. This entry represents interleukin-15 found in mammals. |
