| First Author | Wang W | Year | 1992 |
| Journal | J Dermatol | Volume | 19 |
| Issue | 11 | Pages | 831-5 |
| PubMed ID | 1284074 | Mgi Jnum | J:11869 |
| Mgi Id | MGI:60139 | Doi | 10.1111/j.1346-8138.1992.tb03792.x |
| Citation | Wang W, et al. (1992) Dysregulated expression of cellular adhesion molecules in autoimmune-prone mice. J Dermatol 19(11):831-5 |
| abstractText | The expression of various cell adhesion molecules on lymphocytes and endothelial cells was examined. The strong expression of CD44 antigen on abnormal double negative T cells of lymph nodes was characteristic in MRL-lpr mice. The accumulation of abnormal double negative T cells in swelling lymph nodes was also predominant in MRL-lpr mice; this may result from augmented binding of lymphocytes to endothelial cell surfaces of lymph nodes, possibly due to the failure of Mel-14 antigen shedding from abnormal lymphocyte cell surface. The expression of VCAM-1 antigen was detected in endothelial cell surface of lymph nodes in MRL-lpr mice, which also explains the accumulation of lymphocytes in lymph nodes. However, the expression of VLA-4 antigen on lymphocytes which interact with VCAM-1 on endothelial cells was not significantly different between MRL-lpr and MRL(-)+ mice. |
