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Protein Coding Gene : Ddx39b DEAD box helicase 39b
Primary Identifier  MGI:99240 Organism  mouse, laboratory
Chromosome  17 NCBI Gene Number  53817
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable several functions, including ATP hydrolysis activity; ATP-dependent protein binding activity; and RNA binding activity. Predicted to be involved in several processes, including RNA metabolic process; positive regulation of cell growth involved in cardiac muscle cell development; and positive regulation of macromolecule biosynthetic process. Predicted to act upstream of or within mRNA processing and mRNA transport. Located in nuclear speck. Is expressed in embryo. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human DDX39B (DExD-box helicase 39B).
PHENOTYPE: Mice homozygous for a null allele exhibit complete preweaning lethality while mice heterozygous for the allele exhibit increased susceptibility to gamma radiation. [provided by MGI curators]
  • synonyms:
  • MGC:38799,
  • DNA segment, Chr 17, human D6S81E 1,
  • Bat-1,
  • MGD-MRK-7732,
  • MGC:19235,
  • HLA-B-associated transcript 1A,
  • MGD-MRK-1499,
  • DEAD box helicase 39b,
  • Bat1a,
  • Ddx39b,
  • RIKEN cDNA 0610030D10 gene,
  • expressed sequence AI428441,
  • D6S81Eh,
  • HLA-B-associated transcript 1,
  • DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B,
  • D17H6S81E-1,
  • MGI:3035179,
  • MGD-MRK-15997,
  • Bat1,
  • 0610030D10Rik,
  • AI428441,
  • MGD-MRK-1506,
  • MGI:1915639,
  • MGD-MRK-16027,
  • DNA segment, Chr 17, human D6S81E,
  • D17H6S81E
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