| First Author | Choi M | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 16 | Pages | 3629-34 |
| PubMed ID | 20659469 | Mgi Jnum | J:163620 |
| Mgi Id | MGI:4822514 | Doi | 10.1016/j.febslet.2010.07.037 |
| Citation | Choi M, et al. (2010) The oocyte-specific transcription factor, Nobox, regulates the expression of Pad6, a peptidylarginine deiminase in the oocyte. FEBS Lett 584(16):3629-34 |
| abstractText | Nobox is an oocyte-specific transcriptional regulator. Nobox deficiency disrupts early folliculogenesis and the expression of oocyte-specific genes in mice. In the present study, we found that peptidylarginine deiminase 6 (Pad6) was downregulated in Nobox-null ovaries. Pad6 is preferentially expressed in oocytes and its transcript is detectable at embryonic day 16.5. In addition, we identified one Nobox DNA-binding element (NBE) within the mouse Pad6 promoter. The NBE includes a core sequence TAATTA. Sequence-specific binding of Nobox to the TAATTA motif was confirmed. Nobox overexpression augmented transcriptional activity of a luciferase reporter driven by mouse Pad6. Our findings indicate that Nobox is a critical regulator that orchestrates oocyte-specific genes such as Pad6 during folliculogenesis. |
