| First Author | Oukka M | Year | 2004 |
| Journal | J Exp Med | Volume | 199 |
| Issue | 1 | Pages | 15-24 |
| PubMed ID | 14707112 | Mgi Jnum | J:100058 |
| Mgi Id | MGI:3586433 | Doi | 10.1084/jem.20030421 |
| Citation | Oukka M, et al. (2004) Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells. J Exp Med 199(1):15-24 |
| abstractText | The activator protein 1 (AP-1) transcription factor is a key participant in the control of T cell proliferation, cytokine production, and effector function. In the immune system, AP-1 activity is highest in T cells, suggesting that a subset of T cell-specific coactivator proteins exist to selectively potentiate AP-1 function. Here, we describe that the expression of Schnurri-3, also known as kappa recognition component (KRC), is induced upon T cell receptor signaling in T cells and functions to regulate the expression of the interleukin 2 (IL-2) gene. Overexpression of KRC in transformed and primary T cells leads to increased IL-2 production, whereas dominant-negative KRC, or loss of KRC protein in KRC-null mice, results in diminished IL-2 production. KRC physically associates with the c-Jun transcription factor and serves as a coactivator to augment AP-1-dependent IL-2 gene transcription. |
