Primary Identifier | IPR034926 | Type | Family |
Short Name | TREX2 |
description | TREX1 and TREX2 are DNAQ-like 3'-5' exonucleases that process the 3' termini during DNA replication, repair, and degradation [, ]. TREX1 is expressed in all cells, whereas TREX2 is expressed primarily in keratinocytes []. TREX2 plays an important function during DNA metabolism and cellular proliferation []. Its overexpression plays a role in developing the psoriasis phenotype []. |