| Primary Identifier | IPR004965 | Type | Family |
| Short Name | Paralemmin |
| description | Paralemmin was identified in the chicken lens as a protein with a molecular weight of 65kDa (isoform 1) and a splice variant of 60kDa (isoform 2). Isoform 2 is predominant during infancy and levels of isoform 1 increase with age. Paralemmin is localised to the plasma membrane of fibre cells, and was not detected in the annular pad cells. Its localisation to the short side of the fibre cell and the sites of fibre cell interlocking suggests that paralemmin may play a role in the development of such interdigitating processes []. Palmitoylation is important for localising these proteins to the filopodia of dendritic cells where they have been implicated in the regulation of membrane dynamics and process outgrowth []. Paralemmin-3 is an ATP-binding protein that was shown to interacts with single immunoglobulin IL-1 receptor-related molecule (SIGIRR) and may act as a adapter in the Toll-like receptor (TLR) signalling []. |
