|  Help  |  About  |  Contact Us

Publication : Arthritis induced with cartilage-specific antibodiesis IL-4-dependent.

First Author  Nandakumar KS Year  2006
Journal  Eur J Immunol Volume  36
Issue  6 Pages  1608-18
PubMed ID  16688680 Mgi Jnum  J:115066
Mgi Id  MGI:3690605 Doi  10.1002/eji.200535633
Citation  Nandakumar KS, et al. (2006) Arthritis induced with cartilage-specific antibodiesis IL-4-dependent. Eur J Immunol 36(6):1608-18
abstractText  It is widely believed that IL-4 exerts its influence by profiling the immune response during priming and expansion of immune cells, and thereby modulates the outcome of chronic inflammation. In the present investigation, collagen antibody-induced arthritis (CAIA) was used to delineate the role of IL-4 in a T cell-independent inflammatory phase. Mice predisposed to Th2 cytokines (BALB/c and STAT4-deficient mice) developed a more severe arthritis than mice biased towards Th1 cytokines (C57BL/6 and STAT6-deficient mice). Reduced incidence of CAIA was observed in IL-4-deficient mice compared to control littermates. Infiltrating cells in the paws of IL-4-sufficient mice had increased osteoclast activity and tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta secretion. Massive infiltration of granulocytes and joint and cartilage damage were present in arthritic paws. Depletion of IL-4 suppressed CAIA, which was abrogated by IFN-gamma neutralization. IL-1R- and IL-1RTNFR-deficient mice were completely resistant to CAIA. Thus, IL-4 promotes an antibody-mediated and TNF-alpha/IL-1beta-dependent inflammation in vivo.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

14 Bio Entities

Trail: Publication

0 Expression