| Primary Identifier | IPR015715 | Type | Family |
| Short Name | Ser/Thr_kinase_FAST |
| description | This entry consists of proteins related to the eukaryotic Fas-activated serine/threonine (FAST) kinases that contain several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis []. However, a critical active site residues are not conserved within the family and its kinase activity has been questioned. FASTK localizes to nucleus, cytosol and mitochondria. In mitochondria, FASTK concentrates in mitochondrial RNA granules, where it interacts with the G-rich se-quence factor 1 (GRSF1) and MT-ND6 mRNA []. |
