| First Author | Matsuo K | Year | 2017 |
| Journal | Biol Pharm Bull | Volume | 40 |
| Issue | 6 | Pages | 888-893 |
| PubMed ID | 28566630 | Mgi Jnum | J:301875 |
| Mgi Id | MGI:6507246 | Doi | 10.1248/bpb.b17-00105 |
| Citation | Matsuo K, et al. (2017) Insulin Represses Fasting-Induced Expression of Hepatic Fat-Specific Protein 27. Biol Pharm Bull 40(6):888-893 |
| abstractText | The fat-specific protein 27 (Fsp27) gene belongs to the cell death-inducing DNA fragmentation factor 45-like effector family. Fsp27 is highly expressed in adipose tissue as well as the fatty liver of ob/ob mice. Fsp27 is directly regulated by the peroxisome proliferator-activated receptor gamma (PPARgamma) in livers of genetically obese leptin deficient ob/ob mice. In the present study, Fsp27 was markedly induced by 24 h fasting in genetically normal mouse livers and repressed by refeeding a high sucrose diet. In contrast with the liver, Fsp27 expression was decreased in adipose tissue by fasting and increased by refeeding. Interestingly, fasting-induced Fsp27 liver expression was independent of PPARgamma. Moreover, Fsp27 expression was induced in the insulin-depleted livers of streptozotocin-treated mice. Finally, Fsp27 expression was repressed by direct injection of glucose or insulin in fasting mice. These results suggest that insulin represses Fsp27 expression in the fasting liver. |
