| Primary Identifier | IPR017353 | Type | Family |
| Short Name | Me_CpG-bd_MeCP2 |
| description | Methyl-CpG-binding protein 2 (Mecp2) binds specifically to methylated DNA and represses transcription through the recruitment of chromatin remodeling complexes containing histone deacetylase activities [, ]. It is a multi-functional protein whose function depends on its protein partners and post-translational modifications []. Mecp2 is required for proper mitotic spindle organisation []and affects proliferation and apoptosis []. Mutations in MeCP2 gene cause an X-linked neurodevelopmental disease known as Rett syndrome []. |
