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Protein Domain : Spastin

Primary Identifier  IPR017179 Type  Family
Short Name  Spastin
description  Spastin is an ATP-dependent microtubule severing protein. Microtubule severing may promote reorganisation of cellular microtubule arrays and the release of microtubules from the microtubule organising centre following nucleation [, , ]. In humans, defects in spastin are the cause of spastic paraplegia autosomal dominant type 4 (SPG4). Spastic paraplegia is a neurodegenerative disorder characterised by a slow, gradual, progressive weakness and spasticity of the lower limbs [, ].

1 Child Features

0 Parent Features

3 Protein Domain Regions