Primary Identifier | MGI:7265156 | Allele Type | Targeted |
Attribute String | Humanized sequence | Gene | Bard1 |
Transmission | Germline | Strain of Origin | (C57BL/6J x 129S6/SvEvTac)F1 |
Is Recombinase | false | Is Wild Type | false |
molecularNote | The targeting vector contains a loxP-flanked neomycin inserted into intron 8 and the PEEXI amino acid substitutions L558E (lysine to glutamate, CTG to GAG) and V559E (valine to glutamate, GTA to GAA) inserted into exon 8. Cre-mediated recombination removed the neomycing cassette. The mutation corresponds to the human BARD1-PEELI mutation. |